Research progress on hypoglycemic active components in natural products

Xingyuan Chen, Long Chen, Ruijian Liang, Tianyao Hao, Xuhui Zhang, Yingjun Lian


Diabetes is one of the most challenging health problems worldwide. Commonly used anti-diabetic drugs include insulin, Pramlintide, GLP-1 receptor agonists and oral hypoglycemic. Due to the limitation of these anti-diabetic drugs related to potency, stability and cell toxicity, new drugs isolated from natural materials have been served for alternative and safe anti-diabetic medications in the most recent decade. In this manuscript, pharmacological reaction and molecular mechanism of hypoglycemic active components in natural products were discussed in detail.


Diabetes; natural product; anti-diabetic drug; hypoglycemic active components.

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